The screenshot above provides the location of Vault 63 on the Fallout 76 map. The enemies in this part of the Appalachia are sometimes tough to battle so you may want to take a higher ranked friend with you unless you don’t mind dying a few times.
Be sure to check out some of the links below to see where the other Vaults are located throughout the Appalachia.

List of Unique Random Encounter Event Plans - Fallout 76
How to join the Daily Ops in Fallout 76?
List of the Rarest Items in Fallout 76
Where to find a Nuka-Cola Cranberry in Fallout 76?
Where to find/farm Tick Locations in Fallout 76?
Where to Find/Farm Foxes in Fallout 76?
How to Craft Legendary Weapons in Fallout 76 - Legendary Crafting Guide
How to place a Fallout 1st survival tent in Fallout 76