The screenshot above provides the location of Vault 63 on the Fallout 76 map. The enemies in this part of the Appalachia are sometimes tough to battle so you may want to take a higher ranked friend with you unless you don’t mind dying a few times.
Be sure to check out some of the links below to see where the other Vaults are located throughout the Appalachia.

Power Armor Station Collectible Model - Fallout 76
Where are the Power Armor Locations in Fallout 76?
Where to find/farm Gears in Fallout 76
Where to find/locate a Sheepsquatch in Fallout 76
How to get The Woopsies (Rarest Disease) in Fallout 76?
Where to find the ingredients to make Berry Mentats - Map
What is the Fallout 76 Atlantic City Mysterious Keypad Pass Code?
What is the Max Carry Weight in Fallout 76?